Blood thinners - clopidogrel; Antiplatelet therapy - clopidogrel; Thienopyridines A heart attack or stroke may occur when an area of plaque
(atherosclerosis) ruptures and a clot forms over the location, blocking the flow of blood to the organ's tissues. Antiplatelet drugs may be used to: Your health care provider will choose which one of these drugs are best for your problem. At times, you may be asked to take low dose aspirin along with one of these drugs. Side effects of this medicine may include:
Before you start taking these medicines, tell your provider if:
There are a number of other possible side effects, depending on which drug you are prescribed. For example:
Taking P2Y12 InhibitorsThis medicine is taken as a pill. Your provider may change your dose from time to time. Take this medicine with food and plenty of water to reduce side effects. You may need to stop taking clopidogrel before you have surgery or dental work. Do not just stop taking your medicine without first talking with your provider. Talk with your provider before taking any of these drugs:
Do not take other drugs that may have aspirin or ibuprofen in them before talking with your provider. Read the labels on cold and flu medicines. Ask what other medicines are safe for you to take for aches and pains, colds, or the flu. If you have any type of procedure scheduled, you may need to stop these drugs 5 to 7 days before hand. However, always check with your provider first about whether it is safe to stop. Tell your provider if you are pregnant or planning to become pregnant, or breastfeeding or planning to breastfeed. Women in the later stages of pregnancy should not take clopidogrel. Clopidogrel can be passed to infants through breast milk. Talk with your provider if you have liver or kidney disease. If you miss a dose:
Store these drugs and all other medicines in a cool, dry place. Keep them where children cannot get to them. When to Call the DoctorCall if you have any of these side effects and they do not go away:
ReferencesAbraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol. 2010;56(24):2051-2066. PMID: 21126648 pubmed.ncbi.nlm.nih.gov/21126648/. Fihn SD, Blankenship JC, Alexander KP, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2014;130:1749-1767. PMID: 25070666 pubmed.ncbi.nlm.nih.gov/25070666/. Goldstein LB. Prevention and management of ischemic stroke. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 65. January CT, Wann LS, Alpert JS, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2014;64(21):e1-e76. PMID: 24685669 pubmed.ncbi.nlm.nih.gov/24685669/. Mauri L, Bhatt DL. Percutaneous coronary intervention. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 62. Meschia JF, Bushnell C, Boden-Albala B, et al. Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45(12):3754-3832. PMID: 25355838 pubmed.ncbi.nlm.nih.gov/25355838/. Morrow DA, de Lemos JA. Stable ischemic heart disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Philadelphia, PA: Elsevier; 2019:chap 61. Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2019;50(12):e344-e418. PMID: 31662037 pubmed.ncbi.nlm.nih.gov/31662037/. Version InfoLast reviewed on: 7/30/2020 Reviewed by: Thomas S. Metkus, MD, Assistant Professor of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team. Which signs and symptoms would a patient taking clopidogrel be instructed to report to the healthcare provider immediately?When to Call the Doctor. Any signs of unusual bleeding, such as blood in the urine or stools, nosebleeds, any unusual bruising, heavy bleeding from cuts, black tarry stools, coughing up blood, heavier than usual menstrual bleeding or unexpected vaginal bleeding, vomit that looks like coffee grounds.. Dizziness.. Which symptom is indicative of bleeding in a patient taking warfarin Coumadin )?Signs of internal bleeding include severe headache or changes in strength in one part of the body, blood in the urine, bloody or dark stool, or vomiting blood. These signs should prompt immediate discussion with your healthcare provider, who may order a PT/INR test and an in-person evaluation.
Which is the expected action of heparin when used to treat deep vein thrombosis DVT?Mechanism Of Action
Small amounts of heparin inhibit Factor Xa, and larger amounts inhibit thrombin (Factor IIa). Heparin also prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin stabilizing factor.
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