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Under a Creative Commons license Open access AbstractBackgroundAnaphylaxis is a life-threatening allergic reaction. Several studies reported different anaphylactic reactions according to the causative substances. However, a comparison of anaphylaxis for each cause has not been done. This study was conducted to identify common causes of anaphylaxis, characteristics of anaphylactic reaction for each cause and to analyze the factors related to the severity of the reaction. MethodsMedical records of patients who visited the emergency room of Ewha Womans University Mokdong Hospital from March 2003 to April 2016 and diagnosed with anaphylactic shock were retrospectively reviewed. We compared the clinical features of anaphylaxis according to the cause. In addition, the severity of anaphylaxis was analyzed and contributing factors for severe anaphylaxis were reviewed. ResultsA total of 199 patients with anaphylaxis were analyzed. Food was the most common cause (49.7%), followed by drug reaction (36.2%), bee venom (10.1%), and unknown cause (4.0%). Cardiovascular symptoms of syncope and hypotension were more common in drug-induced anaphylaxis. The incidence of severe anaphylaxis was the highest in anaphylaxis due to drugs (54.2%). Urticaria and other skin symptoms were significantly more common in food-induced anaphylaxis. Risk factors for severe anaphylaxis included older age, male, and drug-induced one. Epinephrine treatment of anaphylaxis was done for 69.7% and 56.9% of patients with food-induced and drug-induced anaphylaxis, respectively. ConclusionsMore severe anaphylaxis developed with drug treatment and in males. Low rate of epinephrine prescription was also observed. Male patients with drug induced anaphylaxis should be paid more attention. KeywordsAnaphylactic shock Anaphylaxis Drug hypersensitivity Food hypersensitivity Risk factors AbbreviationsNOS Not otherwise specified KCD Korean standard classification of disease MAST multiple allergosorbent test ECP eosinophil cationic protein AST aspartate transaminase NSAIDs nonsteroidal anti-inflammatory drugs Cited by (0)© 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V. Anaphylaxis is a severe and potentially life-threatening reaction to a trigger such as an allergy. Anaphylaxis usually develops suddenly and gets worse very quickly. The symptoms include: There may also be other allergy symptoms, including an itchy, raised rash (hives); feeling or being sick; swelling (angioedema) or stomach pain. Anaphylaxis is a medical emergency. It can be very serious if not treated quickly. If someone has symptoms of anaphylaxis:
If you're having an anaphylactic reaction, you can follow these steps yourself if you feel able to. Read about how to treat anaphylaxis for more advice about using auto-injectors and correct positioning. Triggers of anaphylaxisAnaphylaxis is the result of the immune system, the body's natural defence system, overreacting to a trigger. This is often something you're allergic to, but not always. Common anaphylaxis triggers include:
In some cases, there's no obvious trigger. This is known as idiopathic anaphylaxis. Preventing anaphylaxisIf you have a serious allergy or have experienced anaphylaxis before, it's important to try to prevent future episodes. The following can help reduce your risk:
Read more about preventing anaphylaxis
Page last reviewed: 29 November 2019 What causes the most serious anaphylactic reactions?The result is symptoms such as vomiting or swelling. The most common triggers of anaphylaxis are allergens. Medicines, foods, insect stings and bites, and latex most often cause severe allergic reactions. Common culprits are penicillin and other antibiotics, aspirin and aspirin-related products and insulin.
Which of the following agents are responsible for causing the most serious anaphylactic reaction?Causes of Anaphylactic Reactions
Anaphylactic reactions are most commonly caused by the following: Drugs (such as penicillin) Insect stings and animal venoms. Certain foods (particularly eggs, seafood, and nuts)
Which drug is the most common cause of an anaphylactic reaction?Non-Steroidal Anti-inflammatory Drugs (NSAIDs)
Non-Steroidal Anti-inflammatory Drugs are the most frequent triggers of drug-induced anaphylaxis, being responsible for 48.7–57.8% of incidents (10, 18).
Which of the following is most likely to cause anaphylaxis?The most common anaphylaxis triggers in children are food allergies, such as to peanuts and tree nuts, fish, shellfish, wheat, soy, sesame and milk.
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