 Show
CLINICAL TRIALS AND OBSERVATIONSSystematic review and meta-analysis methodologyAbstractSystematic reviews and meta-analyses are being increasingly used to summarize medical literature and identify areas in which research is needed. Systematic reviews limit bias with the use of a reproducible scientific process to search the literature and evaluate the quality of the individual studies. If possible the results are statistically combined into a meta-analysis in which the data are weighted and pooled to produce an estimate of effect. This article aims to provide the reader with a practical overview of systematic review and meta-analysis methodology, with a focus on the process of performing a review and the related issues at each step. Cited by (0)Copyright © 2010 American Society of Hematology Evidence PyramidSystematic reviews and meta-analyses are situated at the top of what is known as the “Evidence Pyramid” (see figure below). As you move up the pyramid the amount of available literature on a given topic decreases, but the relevancy and quality of that literature increases. Systematic reviews and meta-analyses are considered to be the highest quality evidence on a research topic because their study design reduces bias and produces more reliable findings. However, you may not always be able to find (or need to find) the highest level of evidence to answer your research question. In the absence of the best evidence, you then need to consider moving down the pyramid. EBM Pyramid and EBM Page Generator, copyright 2006 Trustees of Dartmouth College and Yale University. All Rights Reserved. A systematic review is a high-level overview of primary research on a particular research question that systematically identifies, selects, evaluates, and synthesizes all high quality research evidence relevant to that question in order to answer it. In other words, it provides an exhaustive summary of scholarly literature related to a particular research topic or question. A systematic review is often written by a panel of experts after reviewing all the information from both published and unpublished studies. The comprehensive nature of a systematic review distinguishes it from traditional literature reviews which typically examine a much smaller set of research evidence and present it from a single author’s perspective. Systematic reviews originated in the biomedical field and currently form the basis of decision-making in Evidence-Based Treatment (EBT) and evidence-based behavioral practice (EBBP). For additional information, read this entry in the e-reference book The A-Z of Social Research: Meta-AnalysesSystematic reviews often use statistical techniques to combine data from the examined individual research studies, and use the pooled data to come to new statistical conclusions. This is called meta-analysis, and it represents a specialized subset of systematic reviews. Not all systematic reviews include meta-analysis, but all meta-analyses are found in systematic reviews. Simply put, a systematic review refers to the entire process of selecting, evaluating, and synthesizing all available evidence, while the term meta-analysis refers to the statistical approach to combining the data derived from a systematic-review. Conclusions produced by meta-analysis are statistically stronger than the analysis of any single study, due to increased numbers of subjects, greater diversity among subjects, or accumulated effects and results. Meta-analyses have become common in the social and biomedical sciences. However, some challenge the validity of meta-analysis, arguing that combining data from disparate studies produces misleading or unreliable results. For additional information, read this entry in e-reference book The Concise Corsini Encyclopedia of Psychology and Behavioral Science: Finding Systematic Reviews & Meta-AnalysesSince there are far fewer systematic reviews and meta-analyses than most other types of research, you will often need to broaden your search terms when searching in the Library’s Databases or the Internet. Also, keep in mind that the term "systematic review" originated in the medical field, so you can expect to see the majority of articles related to medical areas and conditions. Locating systematic reviews and meta-analyses is extremely beneficial not only because they provide high-quality evidence, but also because they will include extensive references to primary studies relevant to your research topic. See the Resources box below for instructions on locating systematic reviews and meta-analyses in the Library databases. Systematic Reviews & Meta-Analyses WorkshopThis workshop provides an introduction to library resources which can be used to locate systematic reviews and meta-analysis studies. Databases
Compiled by the American Psychological Association (APA), APA PsycInfo covers all aspects of psychology, plus the behavioral aspect of education, medicine, sociology, law, management, and other fields. To limit your APA PsycInfo search results to systematic reviews, select Systematic Review within the Methodology box (as shown below) and then type your search terms into the search box.
CINAHL allows you to limit your publication type not only systematic reviews or meta analyses, but also to a "meta synthesis." This publication type value is applied to articles that indicate the presence of a qualitative methodology that integrates results from a number of different, but inter-related studies. To limit your results, select Systematic Reviews (or Meta Analysis or Meta Synthesis) within the Publication Type box (as shown below)
and then type your search terms into the search box. Alternatively,
you may wish to limit your CINAHL search results to Evidence-Based Practice, as shown below. Applying this limiter allows you to limit results to: articles from evidence-based practice journals; articles about evidence-based practice; research articles (including systematic reviews, clinical trials, meta analyses, etc.) and commentaries on research studies (applying practice to research). Selecting Evidence-Based Practice will produce a broader set of results than applying a single publication
type limiter.
Cochrane Library is a collection of six databases that contain different types of high-quality, independent evidence to inform healthcare decision-making, and a seventh database that provides information about Cochrane groups. Select
Advanced Search and then click on Search limits to choose your Cochrane Reviews as shown below.
MEDLINE provides authoritative medical information on medicine, nursing, dentistry, veterinary medicine, the health care system, pre-clinical sciences, and much more. To limit your results to systematic reviews, select Systematic Reviews within the Subject Subset box (as shown below) and then type your search terms into the search box.
Ovid Nursing Full Text is a collection of unique scholarly nursing journals. with subjects ranging from alternative medicine to perinatal nursing. On the OVID Basic Search screen, select from among the options under the field EBM-Evidence Based Medicine, as shown below. To select both Meta Analysis and Systematic Review, hold down the Control button on your keyboard.
PubMed systematic reviews cover a broad set of articles that build consensus on biomedical topics and medical genetics. PubMed also includes meta-analyses, reviews of clinical trials, evidence-based medicine, consensus development conferences, and guidelines. After doing your search, go to the Article Type limit within the left-hand column and select Meta-Analysis or Systematic Review. Note that the Systematic Reviews filter in PubMed will include meta-analyses results. If however, you want to search for only for meta-analyses, select the Meta-Analysis filter under Article Type. You will need to deselect everything in this filter except Meta-Analysis. Alternatively, you can also search for systematic reviews in PubMed by using the Clinical Queries search page. Results of searches on this page are limited to specific clinical research areas.
Roadrunner Search is a great starting point for your research as it searches approximately 95% of the library’s database content, including articles, e-books and videos. To include systematic reviews in your Roadrunner search results, include the phrase
“systematic review” in one of the search boxes and change the drop-down menu to TI Title (as shown below).
Web of Knowledge provides access to current and retrospective bibliographic information, author abstracts, and cited references in social science journals that cover more than 50 disciplines. Note there is no full-text within this database. To include systematic reviews in your Web of Knowledge search results, enter your topic keyword on the top line for Topic. On the second line, type “systematic review” and change the drop-down box to Title (as shown below). Additional Resources
Was this resource helpful?What statistical analysis is used for systematic review?During the systematic review process, the quality of studies is evaluated, and a statistical meta-analysis of the study results is conducted on the basis of their quality. A meta-analysis is a valid, objective, and scientific method of analyzing and combining different results.
What methods are used in a systematic review?The steps for implementing a systematic review include (i) correctly formulating the clinical question to answer (PICO), (ii) developing a protocol (inclusion and exclusion criteria), (iii) performing a detailed and broad literature search and (iv) screening the abstracts of the studies identified in the search and ...
Which statistical technique is used for combining the results of many studies on the same subject?A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting measurements that are expected to have some degree of error.
What is the type of study that uses a statistical technique to combine the results of several to many smaller studies?Meta-analysis is a statistical method to combine results of different studies, especially those with small sample size or with conflicting results. Meta-analysis is often an important component of systematic reviews.
|
What technique is used to combine the statistics from studies included in a systematic review?
zusammenhängende Posts
Urheberrechte © © 2024 decemle Inc.
