Telomerase is fully active in _____ and _____ cells, but almost completely inactive in _____ cells.

1. Aisner, D. L., W. E. Wright, and J. W. Shay. 2002. Telomerase regulation: not just flipping the switch. Curr. Opin. Genet. Dev. 12:80-85. [PubMed] [Google Scholar]

2. Aldous, W. K., A. J. Marean, M. J. DeHart, L. A. Matej, and K. H. Moore. 1999. Effects of tamoxifen on telomerase activity in breast carcinoma cell lines. Cancer 85:1523-1529. [PubMed] [Google Scholar]

3. Ancelin, K., M. Brunori, S. Bauwens, C. E. Koering, C. Brun, M. Ricoul, J. P. Pommier, L. Sabatier, and E. Gilson. 2002. Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2. Mol. Cell. Biol. 22:3474-3487. [PMC free article] [PubMed] [Google Scholar]

4. Armbruster, B. N., S. S. Banik, C. Guo, A. C. Smith, and C. M. Counter. 2001. N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol. Cell. Biol. 21:7775-7786. [PMC free article] [PubMed] [Google Scholar]

5. Artandi, S. E., and R. A. DePinho. 2000. Mice without telomerase: what can they teach us about human cancer? Nat. Med. 6:852-855. [PubMed] [Google Scholar]

6. Asker, C., K. G. Wiman, and G. Selivanova. 1999. p53-induced apoptosis as a safeguard against cancer. Biochem. Biophys. Res. Commun. 265:1-6. [PubMed] [Google Scholar]

7. Avantaggiati, M. L., V. Ogryzko, K. Gardner, A. Giordano, A. S. Levine, and K. Kelly. 1997. Recruitment of p300/CBP in p53-dependent signal pathways. Cell 89:1175-1184. [PubMed] [Google Scholar]

8. Avilion, A. A., M. A. Piatyszek, J. Gupta, J. W. Shay, S. Bacchetti, and C. W. Greider. 1996. Human telomerase RNA and telomerase activity in immortal cell lines and tumor tissues. Cancer Res. 56:645-650. [PubMed] [Google Scholar]

9. Ayer, D. E. 1999. Histone deacetylases: transcriptional repression with SINers and NuRDs. Trends Cell Biol. 9:193-198. [PubMed] [Google Scholar]

10. Bachand, F., and C. Autexier. 1999. Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae. J. Biol. Chem. 274:38027-38031. [PubMed] [Google Scholar]

11. Bachand, F., I. Triki, and C. Autexier. 2001. Human telomerase RNA-protein interactions. Nucleic Acids Res. 29:3385-3393. [PMC free article] [PubMed] [Google Scholar]

12. Backsch, C., N. Wagenbach, M. Nonn, S. Leistritz, E. Stanbridge, A. Schneider, and M. Durst. 2001. Microcell-mediated transfer of chromosome 4 into HeLa cells suppresses telomerase activity. Genes Chromosomes Cancer 31:196-198. [PubMed] [Google Scholar]

13. Baumann, P., and T. R. Cech. 2001. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292:1171-1175. [PubMed] [Google Scholar]

14. Baur, J. A., Y. Zou, J. W. Shay, and W. E. Wright. 2001. Telomere position effect in human cells. Science 292:2075-2077. [PubMed] [Google Scholar]

15. Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 2001. Functional multimerization of the human telomerase reverse transcriptase. Mol. Cell. Biol. 21:6151-6160. [PMC free article] [PubMed] [Google Scholar]

16. Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 2000. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell 11:3329-3340. [PMC free article] [PubMed] [Google Scholar]

17. Beattie, T. L., W. Zhou, M. O. Robinson, and L. Harrington. 1998. Reconstitution of human telomerase activity in vitro. Curr. Biol. 8:177-180. [PubMed] [Google Scholar]

18. Bechter, O. E., W. Eisterer, M. Dlaska, T. Kuhr, and J. Thaler. 2002. CpG island methylation of the hTERT promoter is associated with lower telomerase activity in B-cell lymphocytic leukemia. Exp. Hematol. 30:26-33. [PubMed] [Google Scholar]

19. Belair, C. D., T. R. Yeager, P. M. Lopez, and C. A. Reznikoff. 1997. Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc. Natl. Acad. Sci. USA 94:13677-13682. [PMC free article] [PubMed] [Google Scholar]

20. Betts, D., V. Bordignon, J. Hill, Q. Winger, M. Westhusin, L. Smith, and W. King. 2001. Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proc. Natl. Acad. Sci. USA 98:1077-1082. [PMC free article] [PubMed] [Google Scholar]

21. Blackburn, E. H. 2001. Switching and signaling at the telomere. Cell 106:661-673. [PubMed] [Google Scholar]

22. Blasco, M. A., H. W. Lee, M. P. Hande, E. Samper, P. M. Lansdorp, R. A. DePinho, and C. W. Greider. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34. [PubMed] [Google Scholar]

23. Bodnar, A. G., N. W. Kim, R. B. Effros, and C. P. Chiu. 1996. Mechanism of telomerase induction during T cell activation. Exp. Cell Res. 228:58-64. [PubMed] [Google Scholar]

24. Bodnar, A. G., M. Ouellette, M. Frolkis, S. E. Holt, C. P. Chiu, G. B. Morin, C. B. Harley, J. W. Shay, S. Lichtsteiner, and W. E. Wright. 1998. Extension of life-span by introduction of telomerase into normal human cells. Science 279:349-352. [PubMed] [Google Scholar]

25. Breitschopf, K., A. M. Zeiher, and S. Dimmeler. 2001. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett. 493:21-25. [PubMed] [Google Scholar]

26. Bryan, T. M., J. M. Sperger, K. B. Chapman, and T. R. Cech. 1998. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc. Natl. Acad. Sci. USA 95:8479-8484. [PMC free article] [PubMed] [Google Scholar]

27. Bryce, L. A., N. Morrison, S. F. Hoare, S. Muir, and W. N. Keith. 2000. Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization. Neoplasia 2:197-201. [PMC free article] [PubMed] [Google Scholar]

28. Buchkovich, K. J., and C. W. Greider. 1996. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol. Biol. Cell 7:1443-1454. [PMC free article] [PubMed] [Google Scholar]

29. Campanero, M. R., M. I. Armstrong, and E. K. Flemington. 2000. CpG methylation as a mechanism for the regulation of E2F activity. Proc. Natl. Acad. Sci. USA 97:6481-6486. [PMC free article] [PubMed] [Google Scholar]

30. Chen, J. L., M. A. Blasco, and C. W. Greider. 2000. Secondary structure of vertebrate telomerase RNA. Cell 100:503-514. [PubMed] [Google Scholar]

31. Cheng, A. J., S. K. Liao, S. E. Chow, J. K. Chen, and T. C. Wang. 1997. Differential inhibition of telomerase activity during induction of differentiation in hematopoietic, melanoma, and glioma cells in culture. Biochem. Biophys. Res. Commun. 237:438-444. [PubMed] [Google Scholar]

32. Colgin, L. M., C. Wilkinson, A. Englezou, A. Kilian, M. O. Robinson, and R. R. Reddel. 2000. The hTERTalpha splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia 2:426-432. [PMC free article] [PubMed] [Google Scholar]

33. Collins, K. 1999. Cillate telomerase biochemistry. Annu. Rev. Biochem. 68:178-218. [Google Scholar]

34. Collins, K., and L. Gandhi. 1998. The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex. Proc. Natl. Acad. Sci. USA 95:8485-8490. [PMC free article] [PubMed] [Google Scholar]

35. Collins, K., R. Kobayashi, and C. W. Greider. 1995. Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81:677-686. [PubMed] [Google Scholar]

36. Cong, Y. S., and S. Bacchetti. 2000. Histone deacetylation is involved in the transcriptional repression of hTERT in normal human cells. J. Biol. Chem. 275:35665-35668. [PubMed] [Google Scholar]

37. Cong, Y. S., J. Wen, and S. Bacchetti. 1999. The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum. Mol. Genet. 8:137-142. [PubMed] [Google Scholar]

38. Cook, B. D., J. N. Dynek, W. Chang, G. Shostak, and S. Smith. 2002. Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres. Mol. Cell. Biol. 22:332-342. [PMC free article] [PubMed] [Google Scholar]

39. Counter, C. M., A. A. Avilion, C. E. LeFeeuvre, N. G. Stewart, C. W. Greider, C. B. Harley, and S. Bacchetti. 1992. Telomere shorthening associted with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1921-1929. [PMC free article] [PubMed] [Google Scholar]

40. Counter, C. M., W. C. Hahn, W. Wei, S. D. Caddle, R. L. Beijersbergen, P. M. Lansdorp, J. M. Sedivy, and R. A. Weinberg. 1998. Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc. Natl. Acad. Sci. USA 95:14723-14728. [PMC free article] [PubMed] [Google Scholar]

41. Counter, C. M., M. Meyerson, E. N. Eaton, and R. A. Weinberg. 1997. The catalytic subunit of yeast telomerase. Proc. Natl. Acad. Sci. USA 94:9202-9207. [PMC free article] [PubMed] [Google Scholar]

42. Cress, W. D., and E. Seto. 2000. Histone deacetylases, transcriptional control, and cancer. J. Cell Physiol. 184:1-16. [PubMed] [Google Scholar]

43. Crowe, D. L., and D. C. Nguyen. 2001. Rb and E2F-1 regulate telomerase activity in human cancer cells. Biochim. Biophys. Acta 1518:1-6. [PubMed] [Google Scholar]

44. Cuthbert, A. P., J. Bond, D. A. Trott, S. Gill, J. Broni, A. Marriott, G. Khoudoli, E. K. Parkinson, C. S. Cooper, and R. F. Newbold. 1999. Telomerase repressor sequences on chromosome 3 and induction of permanent growth arrest in human breast cancer cells. J. Natl. Cancer Inst. 91:37-45. [PubMed] [Google Scholar]

45. Davie, J. R., and V. A. Spencer. 1999. Control of histone modifications. J. Cell Biochem. Suppl. 32-33:141-148. [PubMed] [Google Scholar]

46. de Lange, T. 2002. Protection of mammalian telomeres. Oncogene 21:532-540. [PubMed] [Google Scholar]

47. de Lange, T., L. Shiue, R. M. Myers, D. R. Cox, S. L. Naylor, A. M. Killery, and H. E. Varmus. 1990. Structure and variability of human chromosome ends. Mol. Cell. Biol. 10:518-527. [PMC free article] [PubMed] [Google Scholar]

48. DePinho, R. A., N. Schreiber-Agus, and F. W. Alt. 1991. myc family oncogenes in the development of normal and neoplastic cells. Adv. Cancer Res. 57:1-46. [PubMed] [Google Scholar]

49. Dessain, S. K., H. Yu, R. R. Reddel, R. L. Beijersbergen, and R. A. Weinberg. 2000. Methylation of the human telomerase gene CpG island. Cancer Res. 60:537-541. [PubMed] [Google Scholar]

50. Devereux, T. R., I. Horikawa, C. H. Anna, L. A. Annab, C. A. Afshari, and J. C. Barrett. 1999. DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res. 59:6087-6090. [PubMed] [Google Scholar]

51. Dez, C., A. Henras, B. Faucon, D. Lafontaine, M. Caizergues-Ferrer, and Y. Henry. 2001. Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar ribonucleoprotein proteins Cbf5p, Nhp2p and Nop10p. Nucleic Acids Res. 29:598-603. [PMC free article] [PubMed] [Google Scholar]

52. Dhar, S., J. A. Squire, M. P., Hande, R. J. Wellinger, and T. K. Pandita. 2000. Inactivation of 14-3-3 sigma influences telomere behavior and ionizing radiotion-induced chromosomal instability. Mol. Cell. Biol. 20:7764-7772. [PMC free article] [PubMed] [Google Scholar]

53. Doetzlhofer, A., H. Rotheneder, G. Lagger, M. Koranda, V. Kurtev, G. Brosch, E. Wintersberger, and C. Seiser. 1999. Histone deacetylase 1 can repress transcription by binding to Sp1. Mol. Cell. Biol. 19:5504-5511. [PMC free article] [PubMed] [Google Scholar]

54. Dokal, I. 2001. Dyskeratosis congenita. A disease of premature ageing. Lancet 358(Suppl.):S27. [PubMed] [Google Scholar]

55. Dragon, F., V. Pogacic, and W. Filipowicz. 2000. In vitro assembly of human H/ACA small nucleolar ribonucleoproteins reveals unique features of U17. and telomerase RNAs. Mol. Cell. Biol. 20:3037-3048. [PMC free article] [PubMed] [Google Scholar]

56. Eickbush, T. H. 1997. Telomerase and retrotransposons: which came first? Science 277:911-912. [PubMed] [Google Scholar]

57. el-Deiry, W. S. 1998. Regulation of p53 downstream genes. Semin. Cancer Biol. 8:345-357. [PubMed] [Google Scholar]

58. Emili, A., J. Greenblatt, and C. J. Ingles. 1994. Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein. Mol. Cell. Biol. 14:1582-1593. [PMC free article] [PubMed] [Google Scholar]

59. England, N. L., A. P. Cuthbert, D. A. Trott, S. Jezzard, T. Nobori, D. A. Carson, and R. F. Newbold. 1996. Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A). Carcinogenesis 17:1567-1575. [PubMed] [Google Scholar]

60. Englert, C. 1998. WT1-more than a transcription factor? Trends Biochem. Sci. 23:389-393. [PubMed] [Google Scholar]

61. Etheridge, K. T., S. S. Banik, B. N. Armbruster, Y. Zhu, R. M. Terns, M. P. Terns, and C. M. Counter. 2002. The nucleolar localization domain of the catalytic subunit of human telomerase. J. Biol. Chem. 15:15. [PubMed] [Google Scholar]

62. Evans, S. K., and V. Lundblad. 1999. Est1 and Cdc13 as comediators of telomerase access. Science 286:117-120. [PubMed] [Google Scholar]

63. Evans, S. K., and V. Lundblad. 2000. Positive and negative regulation of telomerase access to the telomere. J Cell Sci. 113:3357-3364. [PubMed] [Google Scholar]

64. Feng, J., W. D. Funk, S. S. Wang, S. L. Weinrich, A. A. Avilion, C. P. Chiu, R. R. Adams, E. Chang, R. C. Allsopp, J. Yu, et al. 1995. The RNA component of human telomerase. Science 269:1236-1241. [PubMed] [Google Scholar]

65. Fiset, S., and B. Chabot. 2001. hnRNP A1 may interact simultaneously with telomeric DNA and the human telomerase RNA in vitro. Nucleic Acids Res. 29:2268-2275. [PMC free article] [PubMed] [Google Scholar]

66. Fitzgerald, M. S., K. Riha, F. Gao, S. Ren, T. D. McKnight, and D. E. Shippen. 1999. Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA. Proc. Natl. Acad. Sci. USA 96:14813-14818. [PMC free article] [PubMed] [Google Scholar]

67. Ford, L. P., J. W. Shay, and W. E. Wright. 2001. The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo. RNA 7:1068-1075. [PMC free article] [PubMed] [Google Scholar]

68. Ford, L. P., J. M. Suh, W. E. Wright, and J. W. Shay. 2000. Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase. Mol. Cell. Biol. 20:9084-9091. [PMC free article] [PubMed] [Google Scholar]

69. Forrest, A., and B. Gabrielli. 2001. Cdc25B activity is regulated by 14-3-3. Oncogene 20:4393-4401. [PubMed] [Google Scholar]

70. Forsythe, H. L., J. L. Jarvis, J. W. Turner, L. W. Elmore, and S. E. Holt. 2001. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J. Biol. Chem. 276:15571-15574. [PubMed] [Google Scholar]

71. Friedman, K. L., and T. R. Cech. 1999. Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev. 13:2863-2874. [PMC free article] [PubMed] [Google Scholar]

72. Fujimoto, K., S. Kyo, M. Takakura, T. Kanaya, Y. Kitagawa, H. Itoh, M. Takahashi, and M. Inoue. 2000. Identification and characterization of negative regulatory elements of the human telomerase catalytic subunit (hTERT) gene promoter: possible role of MZF-2 in transcriptional repression of hTERT. Nucleic Acids Res. 28:2557-2562. [PMC free article] [PubMed] [Google Scholar]

73. Fuxe, J., G. Akusjarvi, H. M. Goike, G. Roos, V. P. Collins, and R. F. Pettersson. 2000. Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A. Cell Growth Differ. 11:373-384. [PubMed] [Google Scholar]

74. Gao, Q., L. Singh, A. Kumar, S. Srinivasan, D. E. Wazer, and V. Band. 2001. Human papillomavirus type 16 E6-induced degradation of E6TP1 correlates with its ability to immortalize human mammary epithelial cells. J. Virol. 75:4459-4466. [PMC free article] [PubMed] [Google Scholar]

75. Gewin, L., and D. A. Galloway. 2001. E box-dependent activation of telomerase by human papillomavirus type 16 E6 does not require induction of c-myc. J. Virol. 75:7198-7201. [PMC free article] [PubMed] [Google Scholar]

76. Goldstein, S. 1990. Replicative senescence: the human fibroblast comes of age. Science 249:1129-1133. [PubMed] [Google Scholar]

77. Grandori, C., S. M. Cowley, L. P. James, and R. N. Eisenman. 2000. The Myc/Max/Mad network and the transcriptional control of cell behavior. Annu. Rev. Cell Dev. Biol. 16:653-699. [PubMed] [Google Scholar]

78. Greenberg, R. A., R. C. Allsopp, L. Chin, G. B. Morin, and R. A. De. 1998. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene 16:1723-1730. [PubMed] [Google Scholar]

79. Greenberg, R. A., R. C. O'Hagan, H. Deng, Q. Xiao, S. R. Hann, R. R. Adams, S. Lichtsteiner, L. Chin, G. B. Morin, and R. A. De. 1999. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene 18:1219-1226. [PubMed] [Google Scholar]

80. Greider, C. W. 1998. Telomerase activity, cell proliferation, and cancer. Proc. Natl. Acad. Sci. USA 95:90-92. [PMC free article] [PubMed] [Google Scholar]

81. Greider, C. W. 1999. Telomeres do D-loop-T-loop. Cell 97:419-422. [PubMed] [Google Scholar]

82. Greider, C. W., A. B., and E. H. Blackburn. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43:405-413. [PubMed] [Google Scholar]

83. Griffith, J., A. Bianchi, and T. de Lange. 1998. TRF1. promotes parallel pairing of telomeric tracts in vitro. J. Mol. Biol. 278:79-88. [PubMed] [Google Scholar]

84. Griffith, J. D., L. Comeau, S. Rosenfield, R. M. Stansel, A. Bianchi, H. Moss, and T. de Lange. 1999. Mammalian telomeres end in a large duplex loop. Cell 97:503-514. [PubMed] [Google Scholar]

85. Gu, J., M. Andreeff, J. A. Roth, and B. Fang. 2002. hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity. Gene Ther. 9:30-37. [PubMed] [Google Scholar]

86. Gu, J., S. Kagawa, M. Takakura, S. Kyo, M. Inoue, J. A. Roth, and B. Fang. 2000. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res. 60:5359-5364. [PubMed] [Google Scholar]

87. Gunes, C., S. Lichtsteiner, A. P. Vasserot, and C. Englert. 2000. Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1. Cancer Res. 60:2116-2121. [PubMed] [Google Scholar]

88. Guo, W., M. Okamoto, N. H. Park, and Y. M. Lee. 2001. Cloning and expression of hamster telomerase catalytic subunit cDNA. Int. J. Mol. Med. 8:73-78. [PubMed] [Google Scholar]

89. Hahn, W. C., C. M. Counter, A. S. Lundberg, R. L. Beijersbergen, M. W. Brooks, and R. A. Weinberg. 1999. Creation of human tumour cells with defined genetic elements. Nature 400:464-468. [PubMed] [Google Scholar]

90. Hahn, W. C., S. A. Stewart, M. W. Brooks, S. G. York, E. Eaton, A. Kurachi, R. L. Beijersbergen, J. H. Knoll, M. Meyerson, and R. A. Weinberg. 1999. Inhibition of telomerase limits the growth of human cancer cells. Nat. Med. 5:1164-1170. [PubMed] [Google Scholar]

91. Hande, M. P., A. S. Balajee, and A. T. Natarajan. 1997. Induction of telomerase activity by UV-irradiation in Chinese hamster cells. Oncogene 15:1747-1752. [PubMed] [Google Scholar]

92. Hara, E. T., A. Shinozaki, S. Nakada, and K. Oda. 1991. Cooperative effect of antisense-RB and antisense-p53 in the regulation of cellular senescence. Exp. Cell Res. 179:528-534. [PubMed] [Google Scholar]

93. Harbour, J. W., and D. C. Dean. 2000. Chromatin remodeling and Rb activity. Curr. Opin. Cell Biol. 12:685-689. [PubMed] [Google Scholar]

94. Harley, C. B. 2002. Telomerase is not an oncogene. Oncogene 21:494-502. [PubMed] [Google Scholar]

95. Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460. [PubMed] [Google Scholar]

96. Harley, C. B., Vaziri, H., Counter, C., and R. C. Allsopp. 1992. The telomere hypothesis of cellular aging. Exp. Gerontol. 27:375-382. [PubMed] [Google Scholar]

97. Harrington, L., T. McPhail, V. Mar, W. Zhou, R. Oulton, M. B. Bass, I. Arruda, and M. O. Robinson. 1997. A mammalian telomerase-associated protein. Science 275:973-977. [PubMed] [Google Scholar]

98. Harrington, L., W. Zhou, T. McPhail, R. Oulton, D. S. Yeung, V. Mar, M. B. Bass, and M. O. Robinson. 1997. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 11:3109-3115. [PMC free article] [PubMed] [Google Scholar]

99. Hastie, N. D., M. Dempster, M. G. Dunlop, A. M. Thompson, D. K. Green, and R. C. Allshire. 1990. Telomere reduction in human colorectal carcinoma and with ageing. Nature 346:866-868. [PubMed] [Google Scholar]

100. Hayflick, L. 1965. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:614-636. [PubMed] [Google Scholar]

101. Henderson, B. E., R. K. Ross, and M. C. Pike. 1993. Hormonal chemoprevention of cancer in women. Science 259:633-638. [PubMed] [Google Scholar]

102. Henderson, Y. C., R. L. Breau, T., J. Liu, and G. L. Clayman. 2000. Telomerase activity in head and neck tumors after introduction of wild-type p53, p21, p16 and E2F1 genes by means of recombinant adenovirus. Head Neck July:347-354. [PubMed]

103. Herbert, B., A. E. Pitts, S. I. Baker, S. E. Hamilton, W. E. Wright, J. W. Shay, and D. R. Corey. 1999. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. USA 96:14276-14281. [PMC free article] [PubMed] [Google Scholar]

104. Hisatake, J., T. Kubota, Y. Hisatake, M. Uskokovic, S. Tomoyasu, and H. P. Koeffler. 1999. 5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells. Cancer Res. 59:4023-4029. [PubMed] [Google Scholar]

105. Hiyama, K., Y. Hirai, S. Kyoizumi, M. Akiyama, E. Hiyama, M. A. Piatyszek, J. W. Shay, S. Ishioka, and M. Yamakido. 1995. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J. Immunol. 155:3711-3715. [PubMed] [Google Scholar]

106. Hoey, T., R. O. Weinzierl, G. Gill, J. L. Chen, B. D. Dynlacht, and R. Tjian. 1993. Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell 72:247-260. [PubMed] [Google Scholar]

107. Hollstein, M., K. Rice, M. S. Greenblatt, T. Soussi, R. Fuchs, T. Sorlie, E. Hovig, B. Smith-Sorensen, R. Montesano, and C. C. Harris. 1994. Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res. 22:3551-3555. [PMC free article] [PubMed] [Google Scholar]

108. Holt, S. E., D. L. Aisner, J. Baur, V. M. Tesmer, M. Dy, M. Ouellette, J. B. Trager, G. B. Morin, D. O. Toft, J. W. Shay, W. E. Wright, and M. A. White. 1999. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13:817-826. [PMC free article] [PubMed] [Google Scholar]

109. Holt, S. E., D. L. Aisner, J. W. Shay, and W. E. Wright. 1997. Lack of cell cycle regulation of telomerase activity in human cells. Proc. Natl. Acad. Sci. USA 94:10687-10692. [PMC free article] [PubMed] [Google Scholar]

110. Horikawa, I., P. L. Cable, C. Afshari, and J. C. Barrett. 1999. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res. 59:826-830. [PubMed] [Google Scholar]

111. Hou, M., X. Wang, N. Popov, A. Zhang, X. Zhao, R. Zhou, A. Zetterberg, M. Bjorkholm, M. Henriksson, A. Gruber, and D. Xu. 2002. The histone deacetylase inhibitor trichostatin A derepresses the telomerase reverse transcriptase (hTERT) gene in human cells. Exp Cell Res. 274:25-34. [PubMed] [Google Scholar]

112. Ishii, Y., N. Tsuyama, S. Maeda, H. Tahara, and T. Ide. 1999. Telomerase activity in hybrids between telomerase-negative and telomerase-positive immortal human cells is repressed in the different complementation groups but not in the same complementation group of immortality. Mech. Ageing Dev. 110:175-193. [PubMed] [Google Scholar]

113. Jiang, X. R., G. Jimenez, E. Chang, M. Frolkis, B. Kusler, M. Sage, M. Beeche, A. G. Bodnar, G. M. Wahl, T. D. Tlsty, and C. P. Chiu. 1999. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nat. Genet. 21:111-114. [PubMed] [Google Scholar]

114. Jones, P. A., and D. Takai. 2001. The role of DNA methylation in mammalian epigenetics. Science 293:1068-1070. [PubMed] [Google Scholar]

115. Kanaya, T., S. Kyo, K. Hamada, M. Takakura, Y. Kitagawa, H. Harada, and M. Inoue. 2000. Adenoviral expression of p53 represses telomerase activity through downregulation of human telomerase reverse transcriptase transcription. Clin. Cancer Res. 6:1239-1247. [PubMed] [Google Scholar]

116. Kang, S. S., T. Kwon, D. Y. Kwon, and S. I. Do. 1999. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem. 274:13085-13090. [PubMed] [Google Scholar]

117. Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange. 1999. p53-and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283:1321-1325. [PubMed] [Google Scholar]

118. Karlseder, J., A. Smogorzewska, and T. de Lange. 2002. Senescence induced by altered telomere state, not telomere loss. Science 295:2446-2449. [PubMed] [Google Scholar]

119. Kharbanda, S., V. Kumar, S. Dhar, P. Pandey, C. Chen, P. Majumder, Z. M. Yuan, Y. Whang, W. Strauss, T. K. Pandita, D. Weaver, and D. Kufe. 2000. Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr. Biol. 10:568-575. [PubMed] [Google Scholar]

120. Kharbanda, S., P. Pandey, S. Jin, S. Inoue, A. Bharti, Z. M. Yuan, R. Weichselbaum, D. Weaver, and D. Kufe. 1997. Functional interaction between DNA-PK and c-Abl in response to DNA damage. Nature 386:732-735. [PubMed] [Google Scholar]

121. Kiaris, H., and A. V. Schally. 1999. Decrease in telomerase activity in U-87MG human glioblastomas after treatment with an antagonist of growth hormone-releasing hormone. Proc. Natl. Acad. Sci. USA 96:226-231. [PMC free article] [PubMed] [Google Scholar]

122. Kickhoefer, V. A., A. G. Stephen, L. Harrington, M. O. Robinson, and L. H. Rome. 1999. Vaults and telomerase share a common subunit, TEP1. J. Biol. Chem. 274:32712-32717. [PubMed] [Google Scholar]

123. Kilian, A., D. D. Bowtell, H. E. Abud, G. R. Hime, D. J. Venter, P. K. Keese, E. L. Duncan, R. R. Reddel, and R. A. Jefferson. 1997. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum Mol. Genet. 6:2011-2019. [PubMed] [Google Scholar]

124. Kim, N. W., M. A. Piatyszek, K. R. Prowse, C. B. Harley, M. D. West, P. L. Ho, G. M. Coviello, W. E. Wright, S. L. Weinrich, and J. W. Shay. 1994. Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015. [PubMed] [Google Scholar]

125. Kim, S. H., P. Kaminker, and J. Campisi. 1999. TIN2, a new regulator of telomere length in human cells. Nat. Genet. 23:405-412. [PMC free article] [PubMed] [Google Scholar]

126. Klingelhutz, A. J., S. A. Foster, and J. K. Mc. 1996. Telomerase activation by the E6 gene product of human papillomavirus type 16. Nature 380:79-82. [PubMed] [Google Scholar]

127. Ko, L. J., and C. Prives. 1996. p53: puzzle and paradigm. Genes Dev. 10:1054-1072. [PubMed] [Google Scholar]

128. Koga, S., S. Hirohata, Y. Kondo, T. Komata, M. Takakura, M. Inoue, S. Kyo, and S. Kondo. 2000. A novel telomerase-specific gene therapy: gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter. Hum. Gene Ther. 11:1397-1406. [PubMed] [Google Scholar]

129. Kong, L. B., A. C. Siva, V. A. Kickhoefer, L. H. Rome, and P. L. Stewart. 2000. RNA location and modeling of a WD40 repeat domain within the vault. RNA 6:890-900. [PMC free article] [PubMed] [Google Scholar]

130. Koyanagi, Y., D. Kobayashi, T. Yajima, K. Asanuma, T. Kimura, T. Sato, T. Kida, A. Yagihashi, H. Kameshima, and N. Watanabe. 2000. Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells. Anticancer Res. 20:773-778. [PubMed] [Google Scholar]

131. Ku, W. C., A. J. Cheng, and T. C. Wang. 1997. Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture. Biochem. Biophys. Res. Commun. 241:730-736. [PubMed] [Google Scholar]

132. Kusumoto, M., T. Ogawa, K. Mizumoto, H. Ueno, H. Niiyama, N. Sato, M. Nakamura, and M. Tanaka. 1999. Adenovirus-mediated p53 gene transduction inhibits telomerase activity independent of its effects on cell cycle arrest and apoptosis in human pancreatic cancer cells. Clin. Cancer Res. 5:2140-2147. [PubMed] [Google Scholar]

133. Kyo, S., M. Takakura, T. Kanaya, W. Zhuo, K. Fujimoto, Y. Nishio, A. Orimo, and M. Inoue. 1999. Estrogen activates telomerase. Cancer Res. 59:5917-5921. [PubMed] [Google Scholar]

134. Kyo, S., M. Takakura, T. Kohama, and M. Inoue. 1997. Telomerase activity in human endometrium. Cancer Res. 57:610-614. [PubMed] [Google Scholar]

135. Kyo, S., M. Takakura, T. Taira, T. Kanaya, H. Itoh, M. Yutsudo, H. Ariga, and M. Inoue. 2000. Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res. 28:669-677. [PMC free article] [PubMed] [Google Scholar]

136. LaBranche, H., S. Dupuis, Y. Ben-David, M. R. Bani, R. J. Wellinger, and B. Chabot. 1998. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat. Genet. 19:199-202. [PubMed] [Google Scholar]

137. Laird, P. W., and R. Jaenisch. 1994. DNA methylation and cancer. Hum. Mol. Genet. 3:1487-1495. [PubMed] [Google Scholar]

138. Lanza, R. P., J. B. Cibelli, C. Blackwell, V. J. Cristofalo, M. K. Francis, G. M. Baerlocher, J. Mak, M. Schertzer, E. A. Chavez, N. Sawyer, P. M. Lansdorp, and M. D. West. 2000. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science 288:665-669. [PubMed] [Google Scholar]

139. Lawlor, M. A., and D. R. Alessi. 2001. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. 114:2903-2910. [PubMed] [Google Scholar]

140. Le, S., R. Sternglanz, and C. W. Greider. 2000. Identification of two RNA-binding proteins associated with human telomerase RNA. Mol. Biol. Cell 11:999-1010. [PMC free article] [PubMed] [Google Scholar]

141. Lee, H. W., M. A. Blasco, G. J. Gottlieb, J. W. Horner, 2nd, C. W. Greider, and R. A. DePinho. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392:569-574. [PubMed] [Google Scholar]

142. Leem, S. H., J. A. Londono-Vallejo, J. H. Kim, H. Bui, E. Tubacher, G. Solomon, J. E. Park, I. Horikawa, N. Kouprina, J. C. Barrett, and V. Larionov. 2002. The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions. Oncogene 21:769-777. [PubMed] [Google Scholar]

143. Lendvay, T. S., D. K. Morris, J. Sah, B. Balasubramanian, and V. Lundblad. 1996. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144:1399-1412. [PMC free article] [PubMed] [Google Scholar]

144. Levine, A. J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88:323-331. [PubMed] [Google Scholar]

145. Li, H., L. Zhao, Z. Yang, J. W. Funder, and J. P. Liu. 1998. Telomerase is controlled by protein kinase Calpha in human breast cancer cells. J. Biol. Chem. 273:33436-33442. [PubMed] [Google Scholar]

146. Li, H., L. L. Zhao, J. W. Funder, and J. P. Liu. 1997. Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. J. Biol. Chem. 272:16729-16732. [PubMed] [Google Scholar]

147. Lindsey, J., N. I. McGill, L. A. Lindsey, D. K. Green, and H. J. Cooke. 1991. In vivo loss of telomeric repeats with age in humans. Mutat. Res. 256:45-48. [PubMed] [Google Scholar]

148. Lingner, J., and T. R. Cech. 1996. Purification of telomerase from Euplotes aediculatus: requirement of a primer 3′ overhang. Proc. Natl. Acad. Sci. USA 93:10712-10717. [PMC free article] [PubMed] [Google Scholar]

149. Lingner, J., T. R. Hughes, A. Shevchenko, M. Mann, V. Lundblad, and T. R. Cech. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276:561-567. [PubMed] [Google Scholar]

150. Liu, J. P. 1996. Protein kinase C and its substrates. Mol. Cell Endocrinol. 116:1-29. [PubMed] [Google Scholar]

151. Liu, K., R. J. Hodes, and N. Weng. 2001. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J. Immunol. 166:4826-4830. [PubMed] [Google Scholar]

152. Liu, K., M. M. Schoonmaker, B. L. Levine, C. H. June, R. J. Hodes, and N. P. Weng. 1999. Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc. Natl. Acad. Sci. USA 96:5147-5152. [PMC free article] [PubMed] [Google Scholar]

153. Liu, Y., B. E. Snow, M. P. Hande, G. Baerlocher, V. A. Kickhoefer, D. Yeung, A. Wakeham, A. Itie, D. P. Siderovski, P. M. Lansdorp, M. O. Robinson, and L. Harrington. 2000. Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo. Mol. Cell. Biol. 20:8178-8184. [PMC free article] [PubMed] [Google Scholar]

154. Majumdar, A. S., D. E. Hughes, S. P. Lichtsteiner, Z. Wang, J. S. Lebkowski, and A. P. Vasserot. 2001. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters. Gene Ther. 8:568-578. [PubMed] [Google Scholar]

155. Makarov, V. L., Y. Hirose, and J. P. Langmore. 1997. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell. 88:657-666. [PubMed] [Google Scholar]

156. Malik, H. S., W. D. Burke, and T. H. Eickbush. 2000. Putative telomerase catalytic subunits from Giardia lamblia and Caenorhabditis elegans. Gene 251:101-108. [PubMed] [Google Scholar]

157. Marciniak, R., and L. Guarente. 2001. Human genetics. Testing telomerase. Nature 413:370-371., 373. [PubMed] [Google Scholar]

158. Mason, D. X., C. Autexier, and C. W. Greider. 2001. Tetrahymena proteins p80 and p95 are not core telomerase components. Proc. Natl. Acad. Sci. USA 98:12368-12373. [PMC free article] [PubMed] [Google Scholar]

159. McElligott, R., and R. J. Wellinger. 1997. The terminal DNA structure of mammalian chromosomes. EMBO J. 16:3705-3714. [PMC free article] [PubMed] [Google Scholar]

160. McMahon, S. B., M. A. Wood, and M. D. Cole. 2000. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol. Cell. Biol. 20:556-562. [PMC free article] [PubMed] [Google Scholar]

161. Meier, B., L. Driller, S. Jaklin, and H. M. Feldmann. 2001. New function of CDC13 in positive telomere length regulation. Mol. Cell. Biol. 21:4233-4245. [PMC free article] [PubMed] [Google Scholar]

162. Metz, A. M., R. A. Love, G. A. Strobel, and D. M. Long. 2001. Two telomerase reverse transcriptases (TERTs) expressed in Candida albicans. Biotechnol. Appl. Biochem. 34:47-54. [PubMed] [Google Scholar]

163. Meyerson, M., C. M. Counter, E. N. Eaton, L. W. Ellisen, P. Steiner, S. D. Caddle, L. Ziaugra, R. L. Beijersbergen, M. J. Davidoff, Q. Liu, S. Bacchetti, D. A. Haber, and R. A. Weinberg. 1997. hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 90:785-795. [PubMed] [Google Scholar]

164. Miller, M. C., and K. Collins. 2000. The Tetrahymena p80/p95 complex is required for proper telomere length maintenance and micronuclear genome stability. Mol. Cell 6:827-837. [PubMed] [Google Scholar]

165. Minamino, T., S. A. Mitsialis, and S. Kourembanas. 2001. Hypoxia extends the life span of vascular smooth muscle cells through telomerase activation. Mol. Cell. Biol. 21:3336-3342. [PMC free article] [PubMed] [Google Scholar]

166. Misiti, S., S. Nanni, G. Fontemaggi, Y. S. Cong, J. Wen, H. W. Hirte, G. Piaggio, A. Sacchi, A. Pontecorvi, S. Bacchetti, and A. Farsetti. 2000. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol. Cell. Biol. 20:3764-3771. [PMC free article] [PubMed] [Google Scholar]

167. Mitchell, J. R., J. Cheng, and K. Collins. 1999. A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell. Biol. 19:567-576. [PMC free article] [PubMed] [Google Scholar]

168. Mitchell, J. R., and K. Collins. 2000. Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase. Mol. Cell 6:361-371. [PubMed] [Google Scholar]

169. Mitchell, J. R., E. Wood, and K. Collins. 1999. A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402:551-555. [PubMed] [Google Scholar]

170. Miura, N., N. Onuki, A. Rathi, A. Virmani, S. Nakamoto, Y. Kishimoto, Y. Murawaki, H. Kawasaki, J. Hasegawa, M. Oshimura, W. D. Travis, and A. F. Gazdar. 2001. hTR repressor-related gene on human chromosome 10p15.1. Br J. Cancer 85:1510-1514. [PMC free article] [PubMed] [Google Scholar]

171. Morales, C. P., S. E. Holt, M. Ouellette, K. J. Kaur, Y. Yan, K. S. Wilson, M. A. White, W. E. Wright, and J. W. Shay. 1999. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nat. Genet. 21:115-118. [PubMed] [Google Scholar]

172. Moriarty, T. J., S. Huard, S. Dupuis, and C. Autexier. 2002. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Mol. Cell. Biol. 22:1253-1265. [PMC free article] [PubMed] [Google Scholar]

173. Murphy, M., J. Ahn, K. K. Walker, W. H. Hoffman, R. M. Evans, A. J. Levine, and D. L. George. 1999. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Genes Dev. 13:2490-2501. [PMC free article] [PubMed] [Google Scholar]

174. Muslin, A. J., and H. Xing. 2000. 14-3-3 proteins: regulation of subcellular localization by molecular interference. Cell. Signal. 12:703-709. [PubMed] [Google Scholar]

175. Nakabayashi, K., H. Ogino, E. Michishita, N. Satoh, and D. Ayusawa. 1999. Introduction of chromosome 7 suppresses telomerase with shortening of telomeres in a human mesothelial cell line. Exp. Cell Res. 252:376-382. [PubMed] [Google Scholar]

176. Nakamura, T. M., and T. R. Cech. 1998. Reversing time: origin of telomerase. Cell 92:587-590. [PubMed] [Google Scholar]

177. Nakamura, T. M., G. B. Morin, K. B. Chapman, S. L. Weinrich, W. H. Andrews, J. Lingner, C. B. Harley, and T. R. Cech. 1997. Telomerase catalytic subunit homologs from fission yeast and human. Science 277:955-959. [PubMed] [Google Scholar]

178. Nakayama, J., M. Saito, H. Nakamura, A. Matsuura, and F. Ishikawa. 1997. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell. 88:875-884. [PubMed] [Google Scholar]

179. Nakayama, Y., H. Sakamoto, K. Satoh, and T. Yamamoto. 2000. Tamoxifen and gonadal steroids inhibit colon cancer growth in association with inhibition of thymidylate synthase, survivin and telomerase expression through estrogen receptor beta mediated system. Cancer Lett. 161:63-71. [PubMed] [Google Scholar]

180. Nguyen, D. C., and D. L. Crowe. 1999. Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity. Biochim. Biophys. Acta 1445:207-215. [PubMed] [Google Scholar]

181. Nielsen, S. J., R. Schneider, U. M. Bauer, A. J. Bannister, A. Morrison, D. O'Carroll, R. Firestein, M. Cleary, T. Jenuwein, R. E. Herrera, and T. Kouzarides. 2001. Rb targets histone H3 methylation and HP1 to promoters. Nature 412:561-565. [PubMed] [Google Scholar]

182. Nishimoto, A., N. Miura, I. Horikawa, H. Kugoh, Y. Murakami, S. Hirohashi, H. Kawasaki, A. F. Gazdar, J. W. Shay, J. C. Barrett, and M. Oshimura. 2001. Functional evidence for a telomerase repressor gene on human chromosome 10p15.1. Oncogene 20:828-835. [PubMed] [Google Scholar]

183. Oguchi, K., H. Liu, K. Tamura, and H. Takahashi. 1999. Molecular cloning and characterization of AtTERT, a telomerase reverse transcriptase homolog in Arabidopsis thaliana. FEBS Lett. 457:465-469. [PubMed] [Google Scholar]

184. Oh, S., Y. Song, J. Yim, and T. K. Kim. 1999. The Wilms' tumor 1 tumor suppressor gene represses transcription of the human telomerase reverse transcriptase gene. J. Biol. Chem. 274:37473-37478. [PubMed] [Google Scholar]

185. Oh, S., Y. H. Song, U. J. Kim, J. Yim, and T. K. Kim. 1999. In vivo and in vitro analyses of Myc for differential promoter activities of the human telomerase (hTERT) gene in normal and tumor cells. Biochem. Biophys. Res. Commun. 263:361-365. [PubMed] [Google Scholar]

186. Oh, S., Y. H. Song, J. Yim, and T. K. Kim. 2000. Identification of Mad as a repressor of the human telomerase (hTERT) gene. Oncogene. 19:1485-1490. [PubMed] [Google Scholar]

187. Oh, S. T., S. Kyo, and L. A. Laimins. 2001. Telomerase activation by human papillomavirus type 16 E6 protein: induction of human telomerase reverse transcriptase expression through Myc and GC-rich Sp1 binding sites. J. Virol. 75:5559-5566. [PMC free article] [PubMed] [Google Scholar]

188. Olson, M. O., M. Dundr, and A. Szebeni. 2000. The nucleolus: an old factory with unexpected capabilities. Trends Cell Biol. 10:189-196. [PubMed] [Google Scholar]

189. Oshimura, M., and J. C. Barrett. 1997. Multiple pathways to cellular senescence: role of telomerase repressors. Eur. J. Cancer. 33:710-715. [PubMed] [Google Scholar]

190. Ouellette, M. M., D. L. Aisner, I. Savre-Train, W. E. Wright, and J. W. Shay. 1999. Telomerase activity does not always imply telomere maintenance. Biochem. Biophys. Res. Commun. 254:795-803. [PubMed] [Google Scholar]

191. Ouellette, M. M., M. Liao, B. S. Herbert, M. Johnson, S. E. Holt, H. S. Liss, J. W. Shay, and W. E. Wright. 2000. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J. Biol. Chem. 275:10072-10076. [PubMed] [Google Scholar]

192. Pandita, T. K. 2002. ATM function and telomere stability. Oncogene 21:611-618. [PubMed] [Google Scholar]

193. Peng, C. Y., P. R. Graves, R. S. Thoma, Z. Wu, A. S. Shaw, and H. Piwnica-Worms. 1997. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science 277:1501-1505. [PubMed] [Google Scholar]

194. Pfeffer, L. M., C. A. Dinarello, R. B. Herberman, B. R. Williams, E. C. Borden, R. Bordens, M. R. Walter, T. L. Nagabhushan, P. P. Trotta, and S. Pestka. 1998. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res. 58:2489-2499. [PubMed] [Google Scholar]

195. Pogacic, V., F. Dragon, and W. Filipowicz. 2000. Human H/ACA small nucleolar ribonucleoproteins and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Mol. Cell. Biol. 20:9028-9040. [PMC free article] [PubMed] [Google Scholar]

196. Poole, J. C., L. G. Andrews, and T. O. Tollefsbol. 2001. Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene. 269:1-12. [PubMed] [Google Scholar]

197. Pugh, B. F., and R. Tjian. 1991. Transcription from a TATA-less promoter requires a multisubunit TFIID complex. Genes Dev. 5:1935-1945. [PubMed] [Google Scholar]

198. Rama, S., Y. Suresh, and A. J. Rao. 2001. Regulation of telomerase during human placental differentiation: a role for TGFbeta1. Mol. Cell. Endocrinol. 182:233-248. [PubMed] [Google Scholar]

199. Ramirez, R. D., C. P. Morales, B. S. Herbert, J. M. Rohde, C. Passons, J. W. Shay, and W. E. Wright. 2001. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes Dev. 15:398-403. [PMC free article] [PubMed] [Google Scholar]

200. Rapp, L., and J. J. Chen. 1998. The papillomavirus E6 proteins. Biochim. Biophys. Acta 1378:F1-19. [PubMed] [Google Scholar]

201. Razin, A. 1998. CpG methylation, chromatin structure and gene silencing-a three-way connection. EMBO J. 17:4905-4908. [PMC free article] [PubMed] [Google Scholar]

202. Reik, W., and W. Dean. 2001. DNA methylation and mammalian epigenetics. Electrophoresis 22:2838-2843. [PubMed] [Google Scholar]

203. Rideout, W. M., 3rd, K. Eggan, and R. Jaenisch. 2001. Nuclear cloning and epigenetic reprogramming of the genome. Science 293:1093-1098. [PubMed] [Google Scholar]

204. Rohde, V., H. P. Sattler, T. Bund, H. Bonkhoff, T. Fixemer, C. Bachmann, R. Lensch, G. Unteregger, M. Stoeckle, and B. Wullich. 2000. Expression of the human telomerase reverse transcriptase is not related to telomerase activity in normal and malignant renal tissue. Clin. Cancer Res. 6:4803-4809. [PubMed] [Google Scholar]

206. Seimiya, H., H. Sawada, Y. Muramatsu, M. Shimizu, K. Ohko, K. Yamane, and T. Tsuruo. 2000. Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J. 19:2652-2661. [PMC free article] [PubMed] [Google Scholar]

207. Seto, A. G., A. J. Zaug, S. G. Sobel, S. L. Wolin, and T. R. Cech. 1999. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature 401:177-180. [PubMed] [Google Scholar]

208. Sharma, H. W., J. A. Sokoloski, J. R. Perez, J. Y. Maltese, A. C. Sartorelli, C. A. Stein, G. Nichols, Z. Khaled, N. T. Telang, and R. Narayanan. 1995. Differentiation of immortal cells inhibits telomerase activity. Proc. Natl. Acad. Sci. USA 92:12343-12346. [PMC free article] [PubMed] [Google Scholar]

209. Shay, J. W. 1999. Toward identifying a cellular determinant of telomerase repression. J. Natl. Cancer Inst. 91:4-6. [PubMed] [Google Scholar]

210. Shay, J. W., and S. Bacchetti. 1997. A survey of telomerase activity in human cancer. Eur. J. Cancer 33:787-791. [PubMed] [Google Scholar]

211. Shay, J. W., O. Peirera-Smith, and W. E. Wright. 1991. A role for both RB and p53 in the regulation of the cellular senescence. Exp. Cell Res. 196:33-39. [PubMed] [Google Scholar]

212. Shay, J. W., and W. E. Wright. 2000. Hayflick, his limit, and cellular ageing. Nat. Rev. Mol. Cell. Biol. 1:72-76. [PubMed] [Google Scholar]

213. Shay, J. W., W. E. Wright, D. Brasiskyte, and B. A. Van der Haegen. 1993. E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 8:1407-1413. [PubMed] [Google Scholar]

214. Shay, J. W., and W. E. Wright. 1989. Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 larger T-antigen. Exp. Cell Res. 184:109-118. [PubMed] [Google Scholar]

215. Smith, S., I. Giriat, A. Schmitt, and T. de Lange. 1998. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres. Science 282:1484-1487. [PubMed] [Google Scholar]

216. Smogorzewska, A., B. van Steensel, A. Bianchi, S. Oelmann, M. R. Schaefer, G. Schnapp, and T. de Lange. 2000. Control of human telomere length by TRF1 and TRF2. Mol. Cell. Biol. 20:1659-1668. [PMC free article] [PubMed] [Google Scholar]

217. Smucker, E. J., and J. J. Turchi. 2001. TRF1 inhibits telomere C-strand DNA synthesis in vitro. Biochemistry 40:2426-2432. [PubMed] [Google Scholar]

218. Soda, H., E. Raymond, S. Sharma, R. Lawrence, K. Davidson, M. Oka, S. Kohno, E. Izbicka, and D. D. Von Hoff. 2000. Effects of androgens on telomerase activity in normal and malignant prostate cells in vitro. Prostate 43:161-168. [PubMed] [Google Scholar]

219. Steenbergen, R. D., D. Kramer, C. J. Meijer, J. M. Walboomers, D. A. Trott, A. P. Cuthbert, R. F. Newbold, W. J. Overkamp, M. Z. Zdzienicka, and P. J. Snijders. 2001. Telomerase suppression by chromosome 6 in a human papillomavirus type 16-immortalized keratinocyte cell line and in a cervical cancer cell line. J. Natl. Cancer Inst. 93:865-872. [PubMed] [Google Scholar]

220. Steinert, S., J. W. Shay, and W. E. Wright. 2000. Transient expression of human telomerase extends the life span of normal human fibroblasts. Biochem. Biophys. Res. Commun. 273:1095-1098. [PubMed] [Google Scholar]

221. Strobeck, M. W., K. E. Knudsen, A. F. Fribourg, M. F. DeCristofaro, B. E. Weissman, A. N. Imbalzano, and E. S. Knudsen. 2000. BRG-1 is required for RB-mediated cell cycle arrest. Proc. Natl. Acad. Sci. USA 97:7748-7753. [PMC free article] [PubMed] [Google Scholar]

222. Suske, G. 1999. The Sp-family of transcription factors. Gene 238:291-300. [PubMed] [Google Scholar]

223. Tahara, H., W. Yasui, E. Tahara, J. Fujimoto, K. Ito, K. Tamai, J. Nakayama, F. Ishikawa, and T. Ide. 1999. Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and nontumor tissue sections. Oncogene 18:1561-1567. [PubMed] [Google Scholar]

224. Takakura, M., S. Kyo, T. Kanaya, H. Hirano, J. Takeda, M. Yutsudo, and M. Inoue. 1999. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 59:551-557. [PubMed] [Google Scholar]

225. Takakura, M., S. Kyo, Y. Sowa, Z. Wang, N. Yatabe, Y. Maida, M. Tanaka, and M. Inoue. 2001. Telomerase activation by histone deacetylase inhibitor in normal cells. Nucleic Acids Res. 29:3006-3011. [PMC free article] [PubMed] [Google Scholar]

226. Tanaka, H., M. Shimizu, I. Horikawa, H. Kugoh, J. Yokota, J. C. Barrett, and M. Oshimura. 1998. Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region. Genes Chromosomes Cancer 23:123-133. [PubMed] [Google Scholar]

227. Tanaka, M., S. Kyo, M. Takakura, T. Kanaya, T. Sagawa, K. Yamashita, Y. Okada, E. Hiyama, and M. Inoue. 1998. Expression of telomerase activity in human endometrium is localized to epithelial glandular cells and regulated in a menstrual phase-dependent manner correlated with cell proliferation. Am. J. Pathol. 153:1985-1991. [PMC free article] [PubMed] [Google Scholar]

228. Tesmer, V. M., L. P. Ford, S. E. Holt, B. C. Frank, X. Yi, D. L. Aisner, M. Ouellette, J. W. Shay, and W. E. Wright. 1999. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Mol. Cell. Biol. 19:6207-6216. [PMC free article] [PubMed] [Google Scholar]

229. Tham, W. H., and V. A. Zakian. 2002. Transcriptional silencing at Saccharomyces telomeres: implications for other organisms. Oncogene 21:512-521. [PubMed] [Google Scholar]

230. Thomas, M., L. Yang, and P. J. Hornsby. 2000. Formation of functional tissue from transplanted adrenocortical cells expressing telomerase reverse transcriptase. Nat. Biotechnol. 18:39-42. [PubMed] [Google Scholar]

231. Trouche, D., C. Le Chalony, C. Muchardt, M. Yaniv, and T. Kouzarides. 1997. RB and hbrm cooperate to repress the activation functions of E2F1. Proc. Natl. Acad. Sci. USA 94:11268-11273. [PMC free article] [PubMed] [Google Scholar]

232. Tzukerman, M., C. Shachaf, Y. Ravel, I. Braunstein, O. Cohen-Barak, M. Yalon-Hacohen, and K. L. Skorecki. 2000. Identification of a novel transcription factor binding element involved in the regulation by differentiation of the human telomerase (hTERT) promoter. Mol. Biol. Cell 11:4381-4391. [PMC free article] [PubMed] [Google Scholar]

233. Ulaner, G. A., J. F. Hu, T. H. Vu, L. C. Giudice, and A. R. Hoffman. 1998. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 58:4168-4172. [PubMed] [Google Scholar]

234. Ulaner, G. A., J. F. Hu, T. H. Vu, L. C. Giudice, and A. R. Hoffman. 2001. Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human development. Int. J. Cancer 91:644-649. [PubMed] [Google Scholar]

235. Ulaner, G. A., J. F. Hu, T. H. Vu, H. Oruganti, L. C. Giudice, and A. R. Hoffman. 2000. Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometrium. Int. J. Cancer 85:330-335. [PubMed] [Google Scholar]

236. van Steensel, B., and T. de Lange. 1997. Control of telomere length by the human telomeric protein TRF1. Nature 385:740-743. [PubMed] [Google Scholar]

237. Vaziri, H., and S. Benchimol. 1998. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8:279-282. [PubMed] [Google Scholar]

238. Veldman, T., I. Horikawa, J. C. Barrett, and R. Schlegel. 2001. Transcriptional activation of the telomerase hTERT gene by human papillomavirus type 16 E6 oncoprotein. J. Virol. 75:4467-4472. [PMC free article] [PubMed] [Google Scholar]

239. Vulliamy, T., A. Marrone, F. Goldman, A. Dearlove, M. Bessler, P. J. Mason, and I. Dokal. 2001. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413:432-435. [PubMed] [Google Scholar]

240. Wang, H., and E. H. Blackburn. 1997. De novo telomere addition by Tetrahymena telomerase in vitro. EMBO J. 16:866-879. [PMC free article] [PubMed] [Google Scholar]

241. Wang, J., L. Y. Xie, S. Allan, D. Beach, and G. J. Hannon. 1998. Myc activates telomerase. Genes Dev. 12:1769-1774. [PMC free article] [PubMed] [Google Scholar]

242. Wang, Z., S. Kyo, M. Takakura, M. Tanaka, N. Yatabe, Y. Maida, M. Fujiwara, J. Hayakawa, M. Ohmichi, K. Koike, and M. Inoue. 2000. Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway. Cancer Res. 60:5376-5381. [PubMed] [Google Scholar]

243. Weinrich, S. L., R. Pruzan, L. Ma, M. Ouellette, V. M. Tesmer, S. E. Holt, A. G. Bodnar, S. Lichtsteiner, N. W. Kim, J. B. Trager, R. D. Taylor, R. Carlos, W. H. Andrews, W. E. Wright, J. W. Shay, C. B. Harley, and G. B. Morin. 1997. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 17:498-502. [PubMed] [Google Scholar]

244. Wen, J., Y. S. Cong, and S. Bacchetti. 1998. Reconstitution of wild-type or mutant telomerase activity in telomerase-negative immortal human cells. Hum. Mol. Genet. 7:1137-1141. [PubMed] [Google Scholar]

245. Wenz, C., B. Enenkel, M. Amacker, C. Kelleher, K. Damm, and J. Lingner. 2001. Human telomerase contains two cooperating telomerase RNA molecules. EMBO J. 20:3526-3534. [PMC free article] [PubMed] [Google Scholar]

246. Wick, M., D. Zubov, and G. Hagen. 1999. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 232:97-106. [PubMed] [Google Scholar]

247. Wright, W. E., D. Brasiskyte, M. A. Piatyszek, and J. W. Shay. 1996. Experimental elongation of telomeres extends the lifespan of immortal × normal cell hybrids. EMBL J. 15:1734-1741. [PMC free article] [PubMed] [Google Scholar]

248. Wright, W. E., O. M. Pereira-Smith, and J. W. Shay. 1989. Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol. Cell. Biol. 9:3088-3092. [PMC free article] [PubMed] [Google Scholar]

249. Wright, W. E., M. A. Piatyszek, W. E. Rainey, W. Byrd, and J. W. Shay. 1996. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18:173-179. [PubMed] [Google Scholar]

250. Wright, W. E., and J. W. Shay. 2001. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr. Opin. Genet. Dev. 11:98-103. [PubMed] [Google Scholar]

251. Wright, W. E., and J. W. Shay. 1992. Telomere positional effects and the regulation of cellular senescence. Trends Genet. 8:193-197. [PubMed] [Google Scholar]

252. Wright, W. E., and J. W. Shay. 1992. The two-stage mechanism controlling cellular senescence and immortalization. Exp. Gerontol. 27:383-389. [PubMed] [Google Scholar]

253. Wright, W. E., V. M. Tesmer, K. E. Huffman, S. D. Levene, and J. W. Shay. 1997. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11:2801-2809. [PMC free article] [PubMed] [Google Scholar]

254. Wu, G., W. H. Lee, and P. L. Chen. 2000. NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres. J. Biol. Chem. 275:30618-30622. [PubMed] [Google Scholar]

255. Wu, K. J., C. Grandori, M. Amacker, N. Simon-Vermot, A. Polack, J. Lingner, and R. Dalla-Favera. 1999. Direct activation of TERT transcription by c-MYC. Nat. Genet. 21:220-224. [PubMed] [Google Scholar]

256. Xia, J., Y. Peng, I. S. Mian, and N. F. Lue. 2000. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol. Cell. Biol. 20:5196-5207. [PMC free article] [PubMed] [Google Scholar]

257. Xu, D., S. Erickson, M. Szeps, A. Gruber, O. Sangfelt, S. Einhorn, P. Pisa, and D. Grander. 2000. Interferon alpha downregulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells. Blood 96:4313-4318. [PubMed] [Google Scholar]

258. Xu, D., A. Gruber, M. Bjorkholm, C. Peterson, and P. Pisa. 1999. Suppression of telomerase reverse transcriptase (hTERT) expression in differentiated HL-60 cells: regulatory mechanisms. Br. J. Cancer 80:1156-1161. [PMC free article] [PubMed] [Google Scholar]

259. Xu, D., N. Popov, M. Hou, Q. Wang, M. Bjorkholm, A. Gruber, A. R. Menkel, and M. Henriksson. 2001. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Proc. Natl. Acad. Sci. USA 98:3826-3831. [PMC free article] [PubMed] [Google Scholar]

260. Xu, D., Q. Wang, A. Gruber, M. Bjorkholm, Z. Chen, A. Zaid, G. Selivanova, C. Peterson, K. G. Wiman, and P. Pisa. 2000. Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells. Oncogene 19:5123-5133. [PubMed] [Google Scholar]

261. Xu, H. J., Y. Zhou, W. Ji, G. S. Perng, R. Kruzelock, C. T. Kong, R. C. Bast, G. B. Mills, J. Li, and S. X. Hu. 1997. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene 15:2589-2596. [PubMed] [Google Scholar]

262. Yang, H., S. Kyo, M. Takatura, and L. Sun. 2001. Autocrine transforming growth factor beta suppresses telomerase activity and transcription of human telomerase reverse transcriptase in human cancer cells. Cell Growth Differ. 12:119-127. [PubMed] [Google Scholar]

263. Yang, J., E. Chang, A. M. Cherry, C. D. Bangs, Y. Oei, A. Bodnar, A. Bronstein, C. P. Chiu, and G. S. Herron. 1999. Human endothelial cell life extension by telomerase expression. J. Biol. Chem. 274:26141-26148. [PubMed] [Google Scholar]

264. Yi, X., V. M. Tesmer, I. Savre-Train, J. W. Shay, and W. E. Wright. 1999. Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels. Mol. Cell. Biol. 19:3989-3997. [PMC free article] [PubMed] [Google Scholar]

265. Yi, X., D. M. White, D. L. Aisner, J. A. Baur, W. E. Wright, and J. W. Shay. 2000. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia 2:433-440. [PMC free article] [PubMed] [Google Scholar]

266. Yokoyama, Y., X. Wan, Y. Takahashi, A. Shinohara, and T. Tamaya. 2001. Alternatively spliced variant deleting exons 7 and 8 of the human telomerase reverse transcriptase gene is dominantly expressed in the uterus. Mol. Hum. Reprod. 7:853-857. [PubMed] [Google Scholar]

267. Yu, C. C., S. C. Lo, and T. C. Wang. 2001. Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells. Biochem. J. 355:459-464. [PMC free article] [PubMed] [Google Scholar]

268. Zhang, A., C. Zheng, C. Lindvall, M. Hou, J. Ekedahl, R. Lewensohn, Z. Yan, X. Yang, M. Henriksson, E. Blennow, M. Nordenskjold, A. Zetterberg, M. Bjorkholm, A. Gruber, and D. Xu. 2000. Frequent amplification of the telomerase reverse transcriptase gene in human tumors. Cancer Res. 60:6230-6235. [PubMed] [Google Scholar]

269. Zhang, H. S., and D. C. Dean. 2001. Rb-mediated chromatin structure regulation and transcriptional repression. Oncogene 20:3134-3138. [PubMed] [Google Scholar]

270. Zhang, W., M. A. Piatyszek, T. Kobayashi, E. Estey, M. Andreeff, A. B. Deisseroth, W. E. Wright, and J. W. Shay. 1996. Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clin. Cancer Res. 2:799-803. [PubMed] [Google Scholar]

271. Zhang, X., V. Mar, W. Zhou, L. Harrington, and M. O. Robinson. 1999. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13:2388-2399. [PMC free article] [PubMed] [Google Scholar]

272. Zheng, L., and W. H. Lee. 2001. The retinoblastoma gene: a prototypic and multifunctional tumor suppressor. Exp. Cell Res. 264:2-18. [PubMed] [Google Scholar]

273. Zhou, X. Z., and K. P. Lu. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107:347-359. [PubMed] [Google Scholar]

What is a telomerase quizlet?

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