How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

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How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

Priyal (Stellar Info Tech)

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

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Last Updated: May 27, 2022 3 Minute Read

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How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

Priyal Chugh

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

This person is a verified professional.

Verify your account to enable IT peers to see that you are a professional.

Priyal (Stellar Info Tech)Product Consultant at Stellar Information Technology Pvt. Ltd.

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?


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Outlook is the Office suite’s email and Callender software which provides a wide array of features. Although started off as an email client (which it still is), people use it for managing tasks on the calendar, taking notes, arranging file backups, etc. An error commonly associated with Outlook, one that restricts you from accessing some of its folders and you see an error message that says “The set of folders cannot be opened.” This error can pop up on your screen unusually when you’re trying to launch Outlook. In this article, we will look at a few ways in which this issue can be remediated.

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

Cannot start Microsoft Outlook. Cannot open the Outlook window. The set of folders cannot be opened, The information store could not be opened, The operation failed.

Why can’t I access my folders in Outlook?

If your Outlook data size is large, or if it has become corrupted then the Outlook app may not be able to access or open the data files and folders. You need to reduce the Outlook data size or repair the Outlook installation.

Usually, this error indicates that the Outlook data file, one with all the relevant information, cannot be opened. Make sure that the file isn’t synced with any other backup software at the time when you encounter this error, because if that file is in use, then Outlook won’t get access to it.

  1. Reset the Navigation Pane on Outlook
  2. Disable your Outlook Add-ins
  3. Reduce Outlook Data Size
  4. Recreate your Outlook profile
  5. Repair Microsoft Office

1] Reset the Navigation Pane on Outlook

The first thing you can try right off the bat is resetting your Outlook’s navigation bar using a run command.

  • Open the Run command window with the Win+R shortcut key
  • Paste the following command and press enter:
outlook.exe /resetnavpane
  • There’s a chance that this fixes things for you, but if it doesn’t, then you can try renaming the Outlook.xml file
  • Paste the following command in the Run prompt:
%appdata%\Microsoft\Outlook
  • This will take you to the Outlook appdata folder. Here, locate Outlook.xml, right-click on it, select Rename and enter its new name ‘Outlook.old’
  • Reopen Outlook and check if the issue has been resolved

This fix is, like the rest, only to be implemented if you have an Outlook account set up.

Read: How to speed up Outlook.

2] Disable your Outlook Add-ins

  • Launch Outlook and head over to File
  • From the settings pane on your left, select Options
  • This will open the Outlook Options window. Here, select Add-ins
  • Here, select the Add-ins that you want to disable and save the changes

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

It is also necessary for you to update your Outlook version. Open File > Office account > Office update. Click on Update options and further select Update Now.

Read: Outlook is very slow to load; takes a long time to start.

3] Reduce Outlook Data Size

If it is the large file size of your mailbox that is causing this error to occur, you can tweak the Outlook options to reduce the data size that its files take. Here’s how you can do that:

  • Launch Outlook on your PC and click on File. Here, select Tools and further click on Mailbox Cleanup
  • Single out the items that are needless and can be deleted and confirm it

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

You can empty the Deleted Items folder to cut back on the size of the data file

  • After that, go back to the File page and click on Account Settings
  • Go to Data Files and from the list of files appearing on your screen, select the ones you want to compact
  • Visit the File Settings > click on the Advanced tab > click on Outlook Data File settings and then select Compact Now

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

4] Recreate your Outlook profile

Another solution to the problem is to recreate your Outlook profile. This may fix the issue if there are any corruption issues with your profile.

  • Firstly, you have to erase your profile data using the Registry Editor. Open the Registry Editor and enter the following command line:
Computer\HKEY_CURRENT_USER\SOFTWARE\Microsoft\Office\16.0\Outlook\Profiles
  • Depending on the version of your Microsoft Office, you may have to use the following command line:
Computer\HKEY_CURRENT_USER\SOFTWARE\Microsoft\Office\15
  • Here, delete all the profile folders
  • Now, launch Outlook and click on File
  • Open the Account Settings drop-down and click on Manage Profiles
  • Here, select Show Profiles and click on Add to enter a new user profile by your name

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

Fill in all the necessary credentials and save the changes.

5] Repair Microsoft Office

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

  • Open the Control Panel and select Programs and Features
  • Here, locate the Office suite option and click on it to repair it
  • opt for the Quick Repair option. If that doesn’t work, you can initiate the Online Repair too

Relaunch Outlook to check if the issue has been fixed.

One of the aforementioned solutions would fix up this issue for you, but in the odd chance they don’t work, you can always reinstall Outlook on your PC. We hope that this post was of help to you!

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

How do you fix Cannot start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

Shiwangi loves to dabble with and write about computers. Creating a System Restore Point first before installing new software, and being careful about any third-party offers while installing freeware is recommended.

How do you fix Cannot start Microsoft Outlook Cannot open Outlook window the set of folders Cannot be opened?

Choose Start > Run, and in the Open box, type Outlook. ... .
In the upper-left corner of Outlook, choose File > Options > Add-ins..
Select the check box next to an add-in you want to re-enable, and then choose OK..
Repeat all steps until you've re-enabled all of the original add-ins and revealed the source of the error..

Can't start Microsoft Outlook Cannot open the Outlook window the set of folders Cannot be opened the information store could not be opened?

Run in safe mode Some Add-ins or custom items also may cause your issue, please try to restart your Outlook in safe mode(Windows +R>type "Outlook.exe /safe">enter) Repair your data file If your issue still exists, it may be related to your corrupted data file, please try to repair it to test.

How do you fix Cannot expand the folder the set of folders Cannot be opened the attempt to log on to Microsoft Exchange has failed?

Following are a few effective solutions to fix the error “Outlook the set of folders cannot be opened” are as follows:.
Launch Outlook in Safe Mode..
Update the Outlook application..
Recreate your Outlook Profile..
Turn off Compatibility mode in Outlook..
Repair Office Installation..
Fix Outlook..
Repair PST Using ScanPST Tool..

Can not start Microsoft Office Outlook Cannot open the Outlook window?

Check if Outlook is running in compatibility mode Find the Outlook.exe file on your computer. Right-click the Outlook.exe file, choose Properties, and then choose the Compatibility tab. If any of the boxes on the Compatibility tab are checked, uncheck them, then choose Apply > OK. Restart Outlook.