Is valproic acid a high risk medication?Valproic acid can cause serious birth defects (physical problems that are present at birth), especially affecting the brain and spinal cord and can also cause lower intelligence and problems with movement and coordination, learning, communication, emotions, and behavior in babies exposed to valproic acid before birth.
What are the contraindications of valproic acid?Valproic acid is contraindicated in patients with hepatic disorders, significant hepatic impairment, hypersensitivity to components of the drug and class of drug, urea cycle disorders, mitochondrial disorders, or suspected disorders in patients <2-year-old, and pregnancy (for migraine headache prophylaxis use of ...
How does valproic acid work for seizures?Valproic acid is an anticonvulsant (or anti-epileptic) medicine. It's not fully understood how this medicine works for treating bipolar disorder. However valproic acid is thought to reduce or prevent manic episodes by increasing the amount of a chemical called gamma-aminobutyric acid (GABA) in the brain.
Which medication should be avoided in a patient with a history of seizures?Epilepsy drugs known to have this effect include Carbatrol, Dilantin, phenobarbital, Mysoline, Trileptal, and Topamax.
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