If you're seeing this message, it means we're having trouble loading external resources on our website. Show If you're behind a web filter, please make sure that the domains *.kastatic.org and *.kasandbox.org are unblocked. \( \newcommand{\vecs}[1]{\overset { \scriptstyle \rightharpoonup} {\mathbf{#1}} } \) \( \newcommand{\vecd}[1]{\overset{-\!-\!\rightharpoonup}{\vphantom{a}\smash {#1}}} \)\(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\) \(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\)\(\newcommand{\AA}{\unicode[.8,0]{x212B}}\) Learning Objectives
Many enzymes are simple proteins consisting entirely of one or more amino acid chains. Other enzymes contain a nonprotein component called a cofactor that is necessary for the enzyme’s proper functioning. There are two types of cofactors: inorganic ions [e.g., zinc or Cu(I) ions] and organic molecules known as coenzymes. Most coenzymes are vitamins or are derived from vitamins. Vitamins are organic compounds that are essential in very small (trace) amounts for the maintenance of normal metabolism. They generally cannot be synthesized at adequate levels by the body and must be obtained from the diet. The absence or shortage of a vitamin may result in a vitamin-deficiency disease. In the first half of the 20th century, a major focus of biochemistry was the identification, isolation, and characterization of vitamins. Despite accumulating evidence that people needed more than just carbohydrates, fats, and proteins in their diets for normal growth and health, it was not until the early 1900s that research established the need for trace nutrients in the diet. Because organisms differ in their synthetic abilities, a substance that is a vitamin for one species may not be so for another. Over the past 100 years, scientists have identified and isolated 13 vitamins required in the human diet and have divided them into two broad categories: the fat-soluble vitamins, which include vitamins A, D, E, and K, and the water-soluble vitamins, which are the B complex vitamins and vitamin C. All fat-soluble vitamins contain a high proportion of hydrocarbon structural components. There are one or two oxygen atoms present, but the compounds as a whole are nonpolar. In contrast, water-soluble vitamins contain large numbers of electronegative oxygen and nitrogen atoms, which can engage in hydrogen bonding with water. Most water-soluble vitamins act as coenzymes or are required for the synthesis of coenzymes. The fat-soluble vitamins are important for a variety of physiological functions. The key vitamins and their functions are found in Tables \(\PageIndex{1}\) and \(\PageIndex{2}\). Table \(\PageIndex{2}\): Water-Soluble Vitamins and Physiological FunctionsVitaminCoenzymeCoenzyme FunctionDeficiency Diseasevitamin B1 (thiamine)thiamine pyrophosphatedecarboxylation reactionsberi-berivitamin B2 (riboflavin)flavin mononucleotide or flavin adenine dinucleotideoxidation-reduction reactions involving two hydrogen atoms—vitamin B3 (niacin)nicotinamide adenine dinucleotide or nicotinamide adenine dinucleotide phosphateoxidation-reduction reactions involving the hydride ion (H−)pellagravitamin B6 (pyridoxine)pyridoxal phosphatevariety of reactions including the transfer of amino groups—vitamin B12 (cyanocobalamin)methylcobalamin or deoxyadenoxylcobalaminintramolecular rearrangement reactionspernicious anemiabiotinbiotincarboxylation reactions—folic acidtetrahydrofolatecarrier of one-carbon units such as the formyl groupanemiapantothenic Acidcoenzyme Acarrier of acyl groups—vitamin C (ascorbic acid)noneantioxidant; formation of collagen, a protein found in tendons, ligaments, and bonescurvyVitamins C and E, as well as the provitamin β-carotene can act as antioxidants in the body. Antioxidants prevent damage from free radicals, which are molecules that are highly reactive because they have unpaired electrons. Free radicals are formed not only through metabolic reactions involving oxygen but also by such environmental factors as radiation and pollution.
Free radicals react most commonly react with lipoproteins and unsaturated fatty acids in cell membranes, removing an electron from those molecules and thus generating a new free radical. The process becomes a chain reaction that finally leads to the oxidative degradation of the affected compounds. Antioxidants react with free radicals to stop these chain reactions by forming a more stable molecule or, in the case of vitamin E, a free radical that is much less reactive (vitamin E is converted back to its original form through interaction with vitamin C). SummaryVitamins are organic compounds that are essential in very small amounts for the maintenance of normal metabolism. Vitamins are divided into two broad categories: fat-soluble vitamins and water-soluble vitamins. Most water-soluble vitamins are needed for the formation of coenzymes, which are organic molecules needed by some enzymes for catalytic activity. This page titled 18.9: Enzyme Cofactors and Vitamins is shared under a CC BY-NC-SA 3.0 license and was authored, remixed, and/or curated by Anonymous via source content that was edited to the style and standards of the LibreTexts platform; a detailed edit history is available upon request. Which is often a vitamin binds to an enzyme and plays a role in catalysis?A COFACTOR, such as a vitamin, binds to an enzyme and plays a role in catalysis.
What reactant binds to a catalyst?The reactant in an enzyme-catalyzed reaction is called a substrate.
What role does an enzyme play in catalysis quizlet?What role does an enzyme play in catalysis? An enzyme increases the rate of the forward reaction.
What is the name for the molecule with which the enzyme binds and causes the reaction to take place?To catalyze a reaction, an enzyme will grab on (bind) to one or more reactant molecules. These molecules are the enzyme's substrates.
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A blank, such as a vitamin, binds to an enzyme and plays a role in catalysis.
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